PND17 SELECTING APPROPRIATE OUTCOME MEASURES FOR ALS CLINICAL TRIALS
نویسندگان
چکیده
منابع مشابه
Als Clinical Trials
Most clinical trials are based on current hypotheses that have been developed to explain the pathogenesis of ALS. These hypotheses include mutations of copper/zinc superoxide dismutase (SOD1) in patients with familial ALS (FALS) that result in a toxic gain of function, glutamate excitotoxicity (impaired glutamate transporters), oxidative stress, neurofilament dysfunction, altered calcium homeos...
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ژورنال
عنوان ژورنال: Value in Health
سال: 2019
ISSN: 1098-3015
DOI: 10.1016/j.jval.2019.09.1787